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From Interstate 5, take Highway 42 through Coquille toward Coos Bay. Just west of Coquille, you will encounter a sign for Charleston. At this sign, make a left hand turn and follow North Bank Lane for approximately 4 miles. You will then encounter another sign for Charleston at an intersection where the Coquille River will be visible on your left.
Make this right turn on East Beaver Hill Road and follow the road to the top of a steep hill where it intersects Highway 101. Make a right hand turn onto Highway 101 and follow the road north for one half mile. A green highway sign on your right will point left and read, South Slough Reserve, Charleston, Ocean/Beaches. Turn left on West Beaver Hill Road, which intersects Highway 101, but will turn into Seven Devils Road in a few miles. From the highway, follow this road for 8 miles, past the south entrance to the Reserve (signed) to the main entrance. Watch for a green highway sign: South Slough National Estuarine Research Reserve, ¼ mile. A large, wooden sign at the top of the paved driveway reads, South Slough Reserve Visitors´ Center. The driveway is on the right.
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